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Un induttore del CYP3A4, occur la rifampicina, ha ridotto del 90% la distribuzione del tadalafil, con possibile riduzione della sua efficacia. Altri induttori del CYP3A4, occur fenobarbital, fenitoina e carbamazepina potrebbero ridurre le concentrazioni plasmatiche di tadalafil. Studi in animali hanno mostrato che il tadalafil può essere escreto

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